Académicos

Dr. Edgar Pastene Navarrete
Doctor en Farmacología
ORCID: 0000-0001-5437-9210
Área de investigación:
Química y Farmacología de productos naturales
Laboratorio de Síntesis y Biotransformación de Productos Naturales
Contacto:
epastene@ubiobio.cl / +56-42-246
Publicaciones 2021 – 2026
2026
Correa-Otero, D., Fiallos, N., Gómez-Mediavilla, Á., López, M. G., Siguero-Gómez, C., Bustamante, L., Alarcón-Enos, J., & Pastene-Navarrete, E. (2026). Alkaloids from in vitro cultured Rhodophiala pratensis display neuroprotective effects in murine microglial cell models of inflammation. Plants, 15(8), 1186. https://doi.org/10.3390/plants15081186
2025
Jara-Zapata, P., Arancibia-Ávila, P., Valladares, M. A., Torres-Díaz, C., Pastene, E., & Reyes-Quinteros, N. (2025). Bioprospecting of Chilean Labyrinthulomycetes: Laboratory evaluation of PUFA and carotenoid production in isolates from diverse natural environments. Journal of Eukaryotic Microbiology, 72(5), e70035. https://doi.org/10.1111/jeu.70035
Jara-Zapata, P., Arancibia-Ávila, P., Valladares, M. A., Torres-Díaz, C., Pastene, E., & Reyes-Quinteros, N. (2025). First record of Aplanochytrium on the Chilean coast and its biotechnological potential: Expanding the geographic distribution of Labyrinthulomycetes. Journal of Eukaryotic Microbiology, 72(2), e70007. https://doi.org/10.1111/jeu.70007
Fiallos, N., Acuña, S., Correa-Otero, D., Venegas-Toloza, M., Beldarrain, T., Burgos, J., Fuentes, F., Bustamante, F., Christiansen, G., Roa, V., Schott, E., Alarcón-Enos, J., & Pastene-Navarrete, E. (2025). Centrifugal partition chromatography is a powerful tool for the isolation of antibiofilm quantum carbon dots synthesized by hydrothermal treatment of avocado peels. Molecules, 30(7), 1525. https://doi.org/10.3390/molecules30071525
2024
Arias-Santé, M. F., Fuentes, J., Ojeda, C., Aranda, M., Pastene, E., & Speisky, H. (2024). Amplification of the antioxidant properties of myricetin, fisetin, and morin following their oxidation. Food Chemistry, 435, 137487. https://doi.org/10.1016/j.foodchem.2023.137487
Pettinelli, N., Sabando, C., Bouza Padín, R., Rodríguez-Díaz, M., Pastene, E., Mora, L., Pascual, G., Carrillo-Varela, I., Jara, N., Ide, W., & Rodríguez-Llamazares, S. (2024). Bioactive extracts from grape (Vitis vinifera L. cv. País) leaves: Characterization and encapsulation in poly-3-hydroxybutyrate-co-3-valerate microparticles. Food Bioscience, 59, 103968. https://doi.org/10.1016/j.fbio.2024.103968
Pastene-Burgos, S., Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Espinoza Catalán, L., Bustamante, L., & Alarcón-Enos, J. (2024). Ceanothanes derivatives as peripheric anionic site and catalytic active site inhibitors of acetylcholinesterase: Insights for future drug design. International Journal of Molecular Sciences, 25(13), 7303. https://doi.org/10.3390/ijms25137303
Muñoz-Núñez, E., Pastene-Navarrete, E., Quiroz-Carreño, S., Céspedes-Acuña, C., & Madrid-Villegas, A. (2024). Insecticidal, antifeedant and acetylcholinesterase inhibitory activity of sesquiterpenoids derived from eudesmane, their molecular docking and QSAR. Pesticide Biochemistry and Physiology, 201, 105841. https://doi.org/10.1016/j.pestbp.2024.105841
Berrios-Henríquez, B., Venegas-Toloza, M., Reyes-Fuentes, M., Zúñiga-Arbalti, F., Bustamante, L., García-Cancino, A., Alarcón-Enos, J., & Pastene-Navarrete, E. (2024). Synthesis and isolation of phenol- and thiol-derived epicatechin adducts prepared from avocado peel procyanidins using centrifugal partition chromatography and the evaluation of their antimicrobial and antioxidant activity. Molecules, 29(12), 2872. https://doi.org/10.3390/molecules29122872
2023
Pastene, E., Venegas, M., Fonseca, K., García, A., Zúñiga, F., Alarcón, J., Fiallos, N., Christiansen, G., Correa, D., Bustamante, L., & Avello, M. (2023). Workflow for bio-guided fractionation of antimicrobial polyphenols from Ugni molinae leaves using microfractionation and centrifugal partition chromatography: In vitro and in silico studies. Journal of the Chilean Chemical Society, 68(4), 5977–5986. https://doi.org/10.4067/S0717-97072023000405977
Avello, M., Fernández, M., Fernández, P., Torres, E., & Pastene, E. (2023). Desarrollo inicial de un fitofármaco derivado del jugo de Citrus limon (limón) para el tratamiento de crisis hipertensivas. Revista Chilena de Cardiología, 42(2), 82–89. https://doi.org/10.4067/S0718-85602023000200082
2022
Contreras-Machuca, P. I., Avello, M., Pastene, E., Machuca, Á., Aranda, M., Hernández, V., & Fernández, M. (2022). Chemical characterization and microencapsulation of extracellular fungal pigments. Applied Microbiology and Biotechnology, 106(24), 8021–8034. https://doi.org/10.1007/s00253-022-12255-9
Quiroz-Carreño, S., Muñoz-Núñez, E., Silva, F. L., Devotto-Moreno, L., Seigler, D. S., Pastene-Navarrete, E., Céspedes-Acuña, C. L., & Alarcón-Enos, J. (2022). Cyclopeptide alkaloids from Discaria chacaye (Rhamnaceae) as result of symbiosis with Frankia (Actinomycetales). Chemistry & Biodiversity, 19(9), e202200630. https://doi.org/10.1002/cbdv.202200630
Alarcón-Enos, J., Muñoz-Núñez, E., Gutiérrez, M., Quiroz-Carreño, S., Pastene-Navarrete, E., & Céspedes-Acuña, C. (2022). Dihydro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: Interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials. Journal of Enzyme Inhibition and Medicinal Chemistry, 37(1), 1845–1856. https://doi.org/10.1080/14756366.2022.2091554
Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Seigler, D. S., Céspedes-Acuña, C., Martínez Valenzuela, I., Oppliger Muñoz, M., Salas-Burgos, A., & Alarcón-Enos, J. (2022). Assessments of ceanothanes triterpenes as cholinesterase inhibitors: An investigation of potential
agents with novel inspiration for drug treatment of neurodegenerative diseases. Metabolites, 12(7), 668. https://doi.org/10.3390/metabo12070668
Correa, D. I., Pastene-Navarrete, E., Baeza, M., Bustamante, L., & Alarcón-Enos, J. (2022). Effect of plant growth regulators on alkaloid production in cell cultures of Chilean Amaryllidaceae: Rhodophiala pratensis, Rhodophiala splendens, Rhodophiala advena, and Rhodolirium speciosum. Plant Cell, Tissue and Organ Culture, 151(3), 521–534. https://doi.org/10.1007/s11240-022-02368-4
Trujillo-Mayol, I., Viegas, O., Sobral, M. M. C., Casas-Forero, N., Fiallos, N., Pastene-Navarrete, E., Faria, M. A., Alarcón-Enos, J., Pinho, O., & Ferreira, I. M. P. L. V. O. (2022). In vitro gastric bioaccessibility of avocado peel extract in beef and soy-based burgers and its impact on Helicobacter pylori risk factors. Food Chemistry, 373, 131505. https://doi.org/10.1016/j.foodchem.2021.131505
Silva, F. L., Quiroz-Carreño, S., Ferreira, M. J. P., Wei, Z.-J., Thakur, K., Lv, X., Avila-Acevedo, J. G., Kubo, I., Seigler, D. S., Zengin, G., Sinan, K. I., Mollica, A., Alarcón-Enos, J., Pastene-Navarrete, E., & Céspedes-Acuña, C. L. (2022). Exploring the potential of Fabiana imbricata Ruiz et Pav. (“Pichi”) against pest insects and pathogenic microorganisms for crop protection. South African Journal of Botany, 151, 114–127.
2021
Torres-Vega, J., Gómez-Alonso, S., Pérez-Navarro, J., Alarcón-Enos, J., & Pastene-Navarrete, E. (2021). Polyphenolic compounds extracted and purified from Buddleja globosa Hope (Buddlejaceae) leaves using natural deep eutectic solvents and centrifugal partition chromatography. Molecules, 26(8), 2192. https://doi.org/10.3390/molecules26082192
Del Campo, A., Salamanca, C., Fajardo, A., Díaz-Castro, F., Bustos, C., Calfío, C., Troncoso, R., Pastene-Navarrete, E. R., Acuna-Castillo, C., Milla, L. A., Villarroel, C. A., Cubillos, F. A., Aranda, M., & Rojo, L. E. (2021). Anthocyanins from Aristotelia chilensis prevent olanzapine-induced hepatic-lipid accumulation but not insulin resistance in skeletal muscle cells. Molecules, 26(20), 6149. https://doi.org/10.3390/molecules26206149
Hermosilla, J., Pastene-Navarrete, E., & Acevedo, F. (2021). Electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment: A review. Pharmaceutics, 13(12), 2054. https://doi.org/10.3390/pharmaceutics13122054
