(*Autor de correspondencia)

Penn A, Mir I, Bonnin A, Vacher CM, Nichols E, Escudero C, Gumusoglu S, Stevens H*. Placental-Neural Crosstalk: Biological Mechanisms Shaping Brain Architecture. Journal of Neuroscience. Accepted.
 
Davies B, Seedat F, Bergman L, Cluver C, Lokeswara A, Ma M, Wilbourne M, Jiang S, Galvez A, Handel A, Fower A, Escudero C, Zhang W, Vatish M*. Placental Small EVs Undetected in CSF of Preeclamptic and Eclamptic Women. Biomolecules. Accepted
 
Vásquez W; Lira A; Troncoso F; Sandoval H; Cea LA; Figueroa X; Escudero C; Juan C. Sáez*. Boldine prevents diabetes-induced skeletal muscle dysfunction by inhibiting large-pore channels. Cellular and Molecular Life Sciences. Accepted.
 
Escudero-Guevara E, Troncoso F, Sandoval H, Vargas C, Alarcón M, Mistry HD, Kurlak LO, Vatish M, Moore-Carrasco R, Acurio J, Escudero C*. TSP-1 Endothelial Signaling Impairs Brain Angiogenesis in Preeclampsia. Hypertension. Accepted.
 
Valenzuela-Torres P, Sosa-Macías M, Burgos CF, Damiano AE, Reynoso M, Simental-Mendía LE, Acurio J, Marchat LA, Escudero C*, Galaviz-Hernández C*. Placental SNV rs8192446 in the ADORA2A gene is associated with preeclampsia. A pilot study. Frontiers in Physiology. Vascular Physiology. Accepted.  
 
Vargas-Vaca Y, Bertolotto AM, Navarro E, Olaya Contreras M, Escudero C*.  Prognostic Factors and Sex-Specific Differences in Neonatal Hypoxic–Ischemic Encephalopathy Treated With Therapeutic Hypothermia. Pediatric Neurology. Accepted
 
Escudero C*. Acetaminophen safety revisited: integrating placental transfer with the developing blood-brain barrier. Journal of Physiology. Accepted.
 
Escudero-Guevara E, Sandoval H, Acurio J, Troncoso F, Moore-Carrasco R. Isolation and culture of mouse brain microvascular endothelial cells. JoVE. Accepted.
 
Acurio J, Troncoso F, Escudero-Guevara E, Sandoval H, Ibañez B, Vatish M, Torres-Vergara P, Bergman L, Escudero C*. In vitro evidence that plasma disrupts the blood-brain barrier in eclampsia. Frontiers in Physiology. Accepted.
 
Troncoso F, Sandoval H, Escudero-Guevara E, Nualart F, Ramirez E, Sandaña P, Ek J, Herrock O, Merceron D, Ardiles AO, Vatish M, Acurio J, Escudero C*. Disrupted brain angiogenesis and blood-brain barrier function underlie cognitive deficits in offspring of preeclampsia-like pregnancies. The Journal of Physiology. J Physiol. 2026 Jan 28.  doi: 10.1113/JP289605.  Online ahead of print.
 
Venturini W, Cayo A, Diaz-Serrano G, Sanhueza S, Huilcaman R, Méndez D, Rebolledo-Mira D, Silva-Pereira C, Torres-Orellana F, Troncoso F, Escudero C, Fuentes E, Quest A, Valenzuela C, Tapia JC, 
Brown N*, Moore-Carrasco R*. Extracellular vesicles (EVs) derived from senescent endothelial cells promote platelet activation. International Journal of Molecular Sciences. Int J Mol Sci. 2026 Jan 15;27(2):869. doi: 10.3390/ijms27020869.
 
Celis C, Troncoso F, López E, Escudero-Guevara E, Acurio J, Escudero C*. Dysregulated levels of proangiogenic proteins in the placentas of children with autism spectrum disorder and attention-deficit hyperactivity disorder. Frontiers in Medicine, section Obstetrics and Gynecology. Front Med (Lausanne). 2025 Nov 27;12:1693975. doi: 10.3389/fmed.2025.1693975. eCollection 2025.
 
Carrazana R, Espinoza F, Retamal-Fredes E, Achurra E, Albarrán F, Mardones L, Vidal P, Escudero C, Avila A*. Maternal high-fat diet induces sex-dependent alterations in progenitor cell dynamics and impairs neurogenesis in the embryonic mouse cerebral cortex. Life Sciences. 2025 Oct 26:383:124049.  doi: 10.1016/j.lfs.2025.124049. 
 
Vásquez W, Troncoso F, Lira A, Escudero C, Sáez JC*. Bold restores vascularization and reduces skeletal muscle inflammation in symptomatic mice with dysferlinopathy. International Journal of Molecular Sciences. 2025 Oct 13;26(20):9945.  doi: 10.3390/ijms26209945.
 
Méndez-Pérez L, Ibáñez BO, Rodríguez S, Sen Wong Y, Caamaño D, Navarrete F, Cabezas J, Mançanares A, Escudero C, Rodríguez-Álvarez L, Castro FO*. Extracellular Vesicles Derived from Endometrial Stem Cells Preconditioned with PGE2-Reverse Myofibroblast Phenotype in Mare Endometrial Cells: A Novel Antifibrotic Approach. Molecular Reproduction and Development. 2025 Aug;92(8):e70053.  doi: 10.1002/mrd.70053.
 
Cumsille P, Troncoso F, Sandoval H, Acurio J, Escudero C*. A changepoint detection-based general methodology for robust signal processing: Application to understand the preeclampsia’s mechanisms. Bioengineering. 2025 Jun 19;12(6):675.  doi: 10.3390/bioengineering12060675.
 
Escudero C*, Vatish M. Review: The Potential Role of Placental Extracellular Vesicles in Blood-Brain Barrier Disruption and Neuroinflammation in Preeclampsia. Placenta. 2025 Apr 10: S0143-4004(25)00104-3.
 
Escudero-Guevara E, Sandoval H, Ibáñez B, León J, Acurio J, Troncoso F, Vatish M, López E, Escudero C*. Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells. Journal of Physiology. 2025 Jan 6.  doi: 10.1113/JP285907.  Online ahead of print.
 
Sandoval H, Ibáñez B, Contreras M, Troncoso F, Castro FO, Caamaño D, Méndez L, Escudero-Guevara E, Nualart F, Mistry H, Kurlak L, Vatish M, Acurio J, Escudero C*. Extracellular vesicles from preeclampsia disrupt the blood-brain barrier by reducing claudin-5. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025 Feb;45(2):298-311.  doi: 10.1161/ATVBAHA.124.321077. Epub 2024 Dec 12.
 
González C, Franco JA, Escudero C*, Olaya M*. Brain and brain blood vessels histological description in autopsies of fetuses/neonates born to mothers with hypertension during pregnancy. A case-control study. The Lancet Regional Health – Americas. 2024 Nov 27:41:100955.  doi: 10.1016/j.lana.2024.100955. eCollection 2025 Jan.
 
Friis T*, Bergman L, Hesselman S, Lindström L, Junus K, Cluver C, Escudero C, Wikström AK. Association of gestational hypertension, preeclampsia, and eclampsia with future neurological disorders. JAMA Neurology. 2025 Feb 1;82(2):142-151.  doi: 10.1001/jamaneurol.2024.4426.
 
Moreno  A, Alarcón-Zapata P, Guzmán-Gútierrez E, Radojkovic C, Contreras H, Nova-Lampeti E, Zúñiga FA, Rodriguez-Alvárez L, Escudero C, Lagos P, Aguayo C*. Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+, and CXCR3+ in Individuals with Acute Myocardial Infarction. Biomedicines. 2024 Sep 18;12(9):2119.  doi: 10.3390/biomedicines12092119.
 
Kupka E*, Roberts JM, Mahdy ZA, Escudero C, Bergman L, De Oliveira L on behalf of the Global Pregnancy Collaboration. Aspirin for preeclampsia prevention in low- and middle-income countries: mind the gaps. AJOG Global Reports. 2024 Apr 3;4(2):100352. doi: 10.1016/j.xagr.2024.100352.
 
González-Ortiz M*, Cisterna M, Henning R, Cisterna C, Castro P, Escudero C, Vergara-Barra P, Huerta P. Incidencia de diabetes gestacional en Chile durante el periodo 2001 a 2022). Revista Chilena de Ginecología y Obstetricia. 2024;89(2):100-108.
 
TroncosoF, Sandoval H, IbanezB, López-Espíndola D, Bustos F, Tapia JC, Sandaña P, Escudero-Guevara E, Nualart F, Ramírez E, Powers R, Vatish M, Mistry HD, Kurlak LO, Acurio J, Escudero C*. Reduced brain cortex angiogenesis in the offspring of preeclampsia-like syndrome. Hypertension. 2023 Dec;80(12):2559-2571. doi: 10.1161/HYPERTENSIONAHA.123.21756.
 
Sandoval H, León J, Troncoso F, de la Hoz V, Cisterna A, Contreras M, Castro FO, Ibañez B, Acurio J, Escudero C*. Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas. JOVE. 2024 Jan 26;(203). doi: 10.3791/65867.
 
Granada-Gómez M, Velásquez-Berrío M, Rúa Molina C, San Martín S, Escudero C, Álvarez AM , Cadavid AP*. Modulation of the activation of endothelial nitric oxide synthase and nitrosative stress biomarkers by aspirin triggered lipoxins: A possible mechanism of action of aspirin in the antiphospholipid syndrome. American Journal of Reproductive Immunology. 2023 Aug;90(2):e13753.  doi: 10.1111/aji.13753.
 
Torres-Vergara P*, Rivera R, Escudero C, Penny J. Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs. Advances in Experimental Medicine and Biology. 2023;1428:149-177. doi: 10.1007/978-3-031-32554-0_7.
 
Gonzalez M*, Castro P, Vergara P, Huerta P, Escudero C. COVID-19 on Pregnancy Outcomes, Mental Health and Placenta: Focus in Latin America. Advances in Experimental Medicine and Biology. 2023;1428:269-285. doi: 10.1007/978-3-031-32554-0_12.
 
Torres Y, Celis C, Acurio J, Escudero C*. Language impairment in children of mothers with gestational diabetes, preeclampsia, and preterm delivery: current hypothesis and potential underlying mechanisms. Advances in Experimental Medicine and Biology. 2023:1428:245-267.  doi: 10.1007/978-3-031-32554-0_11.
 
Carrasco-Wong I, González-Ortiz M, Gomes Araujo G, Lima VV, Giachini FR, Stojanova J, Moller A, San Martín S, Escudero P, Damiano A, Sosa-Macias M, Galaviz-Hernandez C, Teran E, Escudero C*. The placental function beyond pregnancy: Insights from Latin America. Advances in Experimental Medicine and Biology. 2023;1428:287-307. doi: 10.1007/978-3-031-32554-0_13.
 
Macías-Salas A, Sosa-Macías M, Barragán-Zúñiga LG, Blanco-Castañeda R, Damiano A, Garcia-Robles R, Ayala-Ramírez P, Bueno-Sánchez J, Giachini F, Escudero C*, Galaviz-Hernandez C*. Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women. Placenta. 2023;135:1-6. doi: 10.1016/j.placenta.2023.02.010.
 
Bergam L*, Escudero C, Cluver C, Hastie R, Torres-Vergara P. Editorial: Preeclampsia and the Brain: Pre-Clinical and Clinical Studies of Cerebral Involvement in Preeclampsia. Frontiers in Physiology, section Clinical and Translational Physiology. Accepted. 2023 Feb 15;14:1151091. doi: 10.3389/fphys.2023.1151091.eCollection 2023.
 
Oporto K, Radojkovic C, Mellisho EA, Zúñiga F, Ormazábal V, Guzmán-Gutiérrez E, Nova-Lamperti E, Rodríguez-Álvarez L, Aranda M, Escudero C, Claudio Aguayo*. Adenosine promoted angiogenesis mediated by the release of small extracellular vesicles from human endothelial progenitor cells. Microvascular Research. 2023;148:104498. 10.1016/j.mvr.2023.104498.
 
Pérez LA, León J, López J, Rojas D, Reyes M, Contreras P, Quest A, Escudero C *, Leyton L *. The GPI-anchored protein Thy-1/CD90 promotes wound healing upon injury to the skin by enhancing skin perfusion. International Journal of Molecular Sciences. 2022 Oct 19;23(20):12539. doi: 10.3390/ijms232012539.
 
Torres-Estay V, Mastri M, Rosario S, Fuenzalida P, Echeverría CE, Flores E, Watts A, Cerda-Infante J, Montecinos VP, Sotomayor PC, Amigo J, Escudero C, Nualart F, Ebos JML, Smiraglia DJ, Godoy SA*. Differential Paracrine Role of the Endothelium in Prostate Cancer Cells. Cancers. 2022 Sep 29;14(19):4750. doi: 10.3390/cancers14194750.
 
Alvarez D, Rua C, Velasquez Berrio M, Ubeimar Cataño J, Escudero C, Cadavid A*. Extracellular vesicles released upon stimulation with antiphospholipid antibodies: An actual direct procoagulant mechanism or a new factor in the lupus anticoagulant paradox?. Journal of Autoimmunity. 2022 Dec;133:102905. doi: 10.1016/j.jaut.2022.102905.
 
Korzeniewski S*, Sutton E, Escudero C, Roberts JM. The Global Pregnancy Collaboration (CoLab) Meeting Proceedings I: Short-and long-term outcomes in offspring whose mothers had preeclampsia: a scoping review of clinical evidence. Frontiers in Medicine. Front. Med. 9:984291. doi: 10.3389/fmed.2022.98429.
 
Cumsille P*, Lara E, Verdugo-Hernández P, Acurio J, Escudero C*. A robust quantitative approach for laser speckle contrast imaging perfusion analysis revealed anomalies in the brain blood flow in offspring mice of preeclampsia. Microvascular Research. 2022 (144):104418. https://doi.org/10.1016/j.mvr.2022.104418
 
Escudero C*, Giachini F, Garcia-Robles R, Galaviz-Hernandez, Damiano A. Editorial: Vascular Dysfunction Beyond Pathological Pregnancies. An International Effort Addressed to Fill the Gaps in Latin America Volume II. Frontiers in Physiology. Front. Physiol. 13:989407. doi: 10.3389/fphys.2022.989407
 
Lara E, Rivera N, González-Bernal A, Rojas D, López D, Rodríguez A, Escudero C*. Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model. Journal of Cerebral Blood Flow and Metabolism. 2022;42(12): 2318–2332. https://doi.org/10.1177/0271678X22112187
 
Meriño M*, Escudero C, Monrroy-Orozco S; Ojeda Morales I, Campos Munoz. Uso bioetico de las tecnologias de salud en los ultimos 20 años: un estudio bibliomeetrico en Scopus. Revista Ethika. Núm. 6 (2022): 20 Años del Centro de Estudios de Ética Aplicada. https://doi.org/10.5354/2452-6037.2022.65869.
 
Escudero C*, Kupka E, Ibañez B, Sandoval H, Troncoso F, Wikström AK, Lopez D, Acurio J, Torres-Vergara P, Bergman L*.  Brain vascular dysfunction in mothers and their children exposed to preeclampsia. Hypertension. 2022;0:10.1161/HYPERTENSIONAHA.122.19408.
 
Reyes C, Nova-Lamperti E, Durán-Sandoval D, Rojas D, Gajardo J, Guzman-Gutierrez E, Bustos-Ruiz C, Ormazábal V, Zuñiga F, Escudero C, Aguayo C*. Loxin reduced the inflammatory response in the liver and the aortic fatty streak formation in mice fed with a high-fat diet. International Journal of Molecular Sciences. 2022, 23(13), 7329; https://doi.org/10.3390/ijms23137329.
 
Torres-Vergara P; Troncoso F; Acurio J; Kupka E; Bergman L; Wikström AK; Escudero C*. Dysregulation of Vascular Endothelial Growth Factor Receptor 2 phosphorylation is associated with disruption of the blood-brain barrier and brain endothelial cell apoptosis induced by plasma from women with preeclampsia. Biochim Biophys Acta Mol Basis Dis. 2022 May 20:166451. doi: 10.1016/j.bbadis.2022.166451.
 
Friis T*; Wikström AK; Acurio J; Leon J; Zetterberg H; Blennow K; Nelander M; Åkerud H; Kaihola H; Cluver C;  Troncoso F; Torres-Vergara P; Escudero C*; Bergman L*. Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia. Cells. 2022 Feb 24;11(5):789. doi: 10.3390/cells11050789.
 
Escudero-Acurio P; Escudero C; Moreno-Castillo C^*.Luxo-fractura compleja de codo con compromiso de húmero distal: reporte de caso clínico. Revista Chilena de Ortopedia y Traumatologia. 2022;63(2):e123-e127. DOI: 10.1055/s-0042-1748027.
 
Ayala-Ramirez P; Gonzalez M; Escudero C; Quinteros-Arciniegas L; Giachini FR; Alves de Freitas R; Damiano A; Garcia-Robles R; RIVATREM. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. A Non-systematic Review of Clinical Presentation, Potential Effects of Physiological Adaptations in Pregnancy, and Placental Vascular Alterations. Frontiers in Physiology. Vascular Physiology. 2022 Mar 30;13:785274. doi: 10.3389/fphys.2022.785274. eCollection 2022.
 
Torres-Vergara P*; Rivera R; Escudero C*. How soluble fms-like tyrosine kinase 1 (sFlt-1) could contribute to blood-brain barrier dysfunction in preeclampsia?. Frontiers in Physiology, section Vascular Physiology. 2022 Feb 8;805082. https://doi.org/10.3389/fphys.2021.805082.
 
Ormazabal V; Nova-Lamperti E; Rojas D; Zuniga FA; Escudero C; Lagos P; Moreno A; Pavez Y; Reyes C; Yanez M; Vidal M; Cabrerar-Vives G; Oporto K; Aguayo C*. Secretome from Human Mesenchymal Stem Cells-Derived Endothelial Cells Promotes Wound Healing in a Type-2 Diabetes Mouse Model. International Journal of Molecular Sciences.  2022, 23(2), 941; https://doi.org/10.3390/ijms23020941.
 
Velasquez Berrio M; Peláez LF; Rojas M; Narvaez-Sanchez R; Velásquez Penagos JA; Escudero C; San Martin S; Cadavid A*. Differences in endothelial activation and dysfunction induced by antiphospholipid antibodies among groups of patients with thrombotic, refractory and non-refractory antiphospholipid syndrome. Frontiers in Physiology. 2021 Dec 2;12:764702. doi: 10.3389/fphys.2021.764702. eCollection 2021.
 
Leon J; Acurio J; Bergman L; Lopez J; Wikström AK; Torres-Vergara P; Troncoso F; Castro FO; Vatish M; Escudero C*. Disruption of the Blood-Brain-Barrier by extracellular vesicles from preeclampsia plasma and hypoxic placentae: attenuation by magnesium sulfate. Hypertension. 2021 Nov;78(5):1423-1433.doi: 10.1161/HYPERTENSIONAHA.121.17744.